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Research Associate - Structural Biologist
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Job Description

Hiring department Mbs-PI-Lambowitz

Monthly salary $4,167+ depending on qualifications

Hours per week 40.00 Flexible from 700AM to 700PM

Posting number 18-02-12-01-0708

Job Status Open

FLSA status Exempt

Earliest Start Date Immediately

Position Duration Terminates on unknown date

Position open to all applicants

Location Austin (main campus)

Number of vacancies 1

General Notes

All applicants must submit a letter of interest, current CV including analysis of publications listed, and three letters of reference/recommendation - two of the three must be from outside UT-Austin. This position is for one year with the possibility of renewal based on performance and available research funding.

Required Application Materials

* A Resume is required in order to apply
* A Letter of Interest is required in order to apply.

Note: The following additional materials are also required for consideration: 3 letters of recommendation - 2 of the 3 letters must be from outside UT Instructions for submission of these materials will be provided at the time the online application has been completed.

Additional Information


To research, with a high degree of independence, the structure, function and mechanism of group II intron reverse transcriptases and related enzymes.

Essential Functions

Express, purify, and characterize full-length and deletion constructs of group II intron reverse transcriptases and related proteins for structural analysis and biotechnological applications, using Fast Protein Liquid Chromatography FPLC and other methods. Characterize wild-type and mutant proteins biochemically and determine conditions under which proteins crystallize in the absence or presence of substrates by sitting or hanging drop methods. Carry out biochemical and biophysical assays. Use in vitro mutagenesis to construct and characterize mutant group II intron reverse transcriptases to modify their biochemical activities. Obtain X-ray crystal structures of reverse transcriptases and related enzymes and their nucleic acid-protein complexes. Test if crystals are suitable for structure determination by X-ray diffraction. Solve structures by crystallographic methods. Obtain SAXS and Cryo-EM structures and other biophysical data for proteins and nucleic acid-protein complexes and construct models for their solution structures. Write manuscripts and assist in the preparation of reports, abstracts, manuscripts and proposals. Make presentations at lab meetings; attend lab meetings and other meetings. Order chemicals and supplies specific to current project. Provide instruction, assistance and mentoring to graduate students.

Marginal/Incidental functions

Other related functions as assigned.

Required qualifications

PhD in biochemistry, biophysics, molecular biology, structural biology or closely related field. History of research productivity as evidenced by a strong publication record. Demonstrated ability to exercise a high degree of independent judgment. Strong written and verbal communication skills and excellent attention to detail. Demonstrated ability to work well with a culturally diverse group of faculty, staff, and students, including the willingness and ability to mentor graduate students. Equivalent combination of relevant education and experience may be substituted as appropriate.

Preferred Qualifications

Demonstrated ability to crystallize proteins and solve structures. Experience with biochemical and biophysical assays. Three years of post-doctoral experience in a relevant field.

Working conditions

Uniforms and/or personal protection equipment (furnished) May work around chemical fumes May work around standard office conditions May work around biohazards May work around chemicals Repetitive use of a keyboard at a workstation Use of manual dexterity

About University of Texas at Austin

The University of Texas at Austin, the largest component of The University of Texas System, is a major research university and home to more than 48,000 students, 2,700 faculty and 17,000 staff members. From teaching and research to public service, the university's activities support its core purpose - to transform lives for the benefit of society through the core values of learning, discovery, freedom, leadership, individual opportunity and responsibility. The mission of The University of Texas at Austin is to achieve excellence in the interrelated areas of undergraduate education, graduate education, research, and public service.

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