No experience
Employment Type:
Full time
Job Category:
Health Care & Medicine
Staff Research Associate III
(This job is no longer available)
UCLA Health | Santa Monica, CA
Grad Date

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Job Description

Job Duties
This position entails high-level, independent research work on two major areas of study: (1) identification and validation of biomarkers that predict sensitivity or resistance to treatment with existing anti-cancer therapeutics and (2) assay development for a novel small molecule discovery pipeline. These major projects require many subtasks and proficiencies including: tissue culture of human cancer cell lines, in vitro drug testing, flow cytometry, Western blotting, ELISA, IF/IHC, siRNA knockdown, cloning and expression of novel transgenes, CRISPR/Cas, in vitro DMPK/ADME assays, amongst others. In addition to these scientific/research tasks, the position has several management and leadership requirements including: training of new laboratory staff on the aforementioned techniques, assisting with budgeting, inventory, and ordering of lab supplies, managing subcontracted projects with outside CROs and collaborators, and assisting in the writing of papers, grants and presentations. Some in vivo work will also be need to be periodically performed, including: Perform procedure of harvesting tumors from nude or S.C.I.D. mice developing them into cell suspensions. Order and handle animals. Collect data, tumor volumes, and tumor marker levels. Ability to multi task and work independently.

Job Qualifications
Skill in handling radioactive materials and wastes. Ability to work with cancer infected cells and use sterile techniques in maintaining cell lines. Skill in doing radioimmunoprecipitation assay using SDS-poly-acrylamide gel-electrophoresis. Skill in testing for Cancerous cells using Western blot and Elisa technique. Ability to clone, purify and insert DNA into vectors. Skill in doing mini-preps and plasmid preps for isolation of DNA. Ability to run horizontal gel-electrophoresis and ultracentrifuge in identifying DNA. Ability in maintaining proper usage of equipment and safety in a biohazard laboratory. Skill in sub-coetaneous injection of rabbits to test for anti-body response. Skill in keeping accurate, complete and clear record of all experiments. Ability to work with animals and knowledge of proper procedure to inject and perform surgery. Working knowledge of Mitochondrial DNA testing. Working knowledge of mycoplasma testing to identify any negative or positive cell contamination. Working knowledge of Data collection which includes but is not limited to: rate of tumor growth, size of tumor growth, excel spreadsheets displaying graphs that compare various drugs and various arms on an experiment (control, new standard drugs, etc.).Working knowledge of organization of Data to present to collaborators. Skill in cutting and staining for various markers. Skill in working with research animals. Knowledge of the ARC policies and procedures.

About UCLA Health

For more than half a century, UCLA Health  has provided the best in healthcare and the latest in medical technology to thepeople of Los Angeles and throughout the world. Today we are one of the most comprehensive and advanced healthcare systems in existence. We are comprised of Ronald Reagan UCLA Medical Center, UCLA Medical Center, Santa Monica, Resnick Neuropsychiatric Hospital at UCLA, Mattel Children’s Hospital UCLA, and the UCLA Medical Group, with offices throughout the region.

Ronald Reagan UCLA Medical Center is consistently ranked by U.S.News & World Report as one of the top five hospitals in the nation and the best medical center in the western United States. The doctors, scientists and caregivers of UCLA are leaders in their fields. Every day, they perform pioneering work across an astounding range of disciplines, from organ transplantation and cardiac surgery to neurosurgery and cancer treatment. Year after year, our people have achieved medical breakthroughs and earned the highest industry honors. And we’re just getting started.

The dedicated professionals of UCLA Health are committed to healing humankind, one patient at a time, by improving health, alleviating suffering, and delivering acts of kindness on a daily basis.