Experience:
No experience
Employment Type:
Full time
Posted:
2/8/2018
Job Category:
Research
Postdoctoral Research Fellow - Chemical Biologist, Department of Biolo
(This job is no longer available)
Revolution Medicines | Redwood City, CA
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Job Description

Job description:

Revolution Medicines Postdoctoral Research Fellow - Chemical Biologist, Department of Biology

REVOLUTION Medicines discovers and develops new drugs that translate frontier cancer targets through exceptional
drug discovery delivering revolutionary medicines on behalf of cancer patients. Our innovative science draws inspiration
from nature and evolution, which offer insights into cancer targets, disease mechanisms and therapeutic approaches. As
a new member of the RevMed team, you will join other outstanding scientists who are helping lead our efforts in the
discovery and development of new medicines for unmet needs in cancer.

The Project:

- The project will explore novel macrocycle drug conjugates that improve cellular penetration and enable access
to classically undruggable oncology targets.
- Select therapeutically relevant targets for which there are existing modulators, but yet remain inaccessible
because of lack of cellular penetration and/or suboptimal pharmacokinetic properties.
- Work with chemists to design and leverage novel beyond rule of 5 molecular approaches to synthesize
macrocycle conjugates and subsequently develop innovative biological strategies to characterize their profiles.

The Opportunity:

- As a post-doctoral research fellow in our Biology Department, you will have the opportunity to join a small team
of motivated scientists in a fast-paced environment focused on the discovery and development of novel
medicines for frontier cancer targets.
- You will work alongside outstanding researchers and collaborators, in the Revolution Medicines Research and
Development team, committed to the prosecution of ground-breaking science with clinical translational impact.
- With access to top capabilities, equipment, expertise and knowledge across chemistry, structural biology, cancer
biology, drug metabolism and pharmacology, you will be able to pursue important scientific questions while
obtaining experience in drug discovery.
- You will be expected to present your research at internal and external meetings and will also have the
opportunity to interact within the greater scientific community, including inviting and hosting outside speakers
of your choice.
- Timely publication of innovative science in high-impact journals is expected along with applicable patent filings.
- Immersion in our high energy start-up environment will provide valuable exposure to world class drug discovery
expertise and position you for career opportunities in pharma, biotechnology, and academia.

Education, training, experience:

Required Experience, Skills, and Education:

- Ph.D. degree with scientific expertise in chemistry, biochemistry and molecular or cell biology.
- Strong track record of research productivity and technical innovation in chemical biology as evidenced by high-
quality, impactful publications.
- Ability to design cell-based experiments using genetic and pharmacological manipulation of proteins and
pathways in relevant cell systems to characterize molecular mode of action of tool compounds.
- Ability to thrive in a multi-discipline team environment is essential and expertise in chemistry, especially as it
relates to probe design is a plus.
- Rigorous, quantitative and detail-oriented experimentalist with excellent written and verbal communication
skills.

Come join the REVOLUTION!

We offer a dynamic, collaborative and scientifically challenging environment plus an excellent benefits package.
Interested candidates may send a cover letter and CV/resume.

Qualifications

Applicants must be eligible to work in the specified location