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Employment Type:
Full time
Job Category:
Scientist, DMPK
(This job is no longer available)
Frontage Laboratories | Exton, PA
Grad Date

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Job Description

For a contract research organization (Frontage Laboratories, Inc. – Exton, PA): conduct in vitro and in vivo metabolism studies using radiolabeled and non-radiolabeled compounds; analyze samples using HPLC coupled to radioactivity detectors and MS detectors (Orbitrap, ion trap, triple stage quadruple instruments) and propose structures of metabolites and metabolic pathways; develop robust sample analysis method and perform metabolites identification, synthesis and isolation in various matrices; design and synthesize custom chemistry library and prodrug and perform compound optimization.


  1. Ph.D. or foreign equivalent degree in Medicinal Chemistry, Analytical Chemistry, Pharmacokinetics or a related field.
  2. 1 year experience in job offered or 1 year research experience. Will accept research experience gained while pursuing graduate degree. This required experience must include 1 year experience in structural optimization in early drug discovery, custom synthesis, prodrug design and synthesis and small molecules drug metabolism studies.
  3. Proficiency in LC-MS/MS, NMR, HPLC, in vivo ADME animal IV, IP dosing, blood and tissue collection and PK protein binding assays.

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About Frontage Laboratories

Frontage Laboratories, Inc. is more than a contract laboratory ... we're a collaborative R & D company dedicated to advancing the development efforts of pharmaceutical companies around the world. We specialize in assisting our partners to resolve complex product development issues through our combined expertise in pharmaceutical analysis, bioanalytical testing and method development, and custom synthesis of investigational compounds. Frontage Laboratories, Inc. has a passion for detail and is committed to following Good Laboratory and Manufacturing P ractices (GLP and GMP). We have an experienced management team and scientific staff (over 75 years of combined technical experience), most of whom have received their training and expertise from such notable companies as Wyeth, Merck, Pharmacia, and Aventis. We have incorporated these experiences into establishing robust laboratory quality systems. Our current clientele range from drug discovery companies, large pharma companies to generic pharmaceutical companies in the US and abroad. Frontage Laboratories, Inc. is fully compliant with cGMP/GLP regulations. We offer quality services, rapid turnaround and competitive pricing.