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Generalist Intern
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D.E. Shaw Research | New York, NY
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Job Description

The D. E. Shaw group is seeking motivated individuals with a desire to learn and contribute to join its internship program. Generalist interns will have the opportunity to work in one of several departments at the firm, such as Corporate Development, Investor Relations, Risk, or the Office of the Chief Operating Officer. Interns will be assigned a manager who will mentor and support their professional development, and they'll have opportunities to learn about the firm and the industry from both internal and external experts.

About D.E. Shaw Research

About the lab

D. E. Shaw Research ("DESRES") is an independent research laboratory that conducts basic scientific research in the field of computational biochemistry under the direct scientific leadership of David Shaw, who serves as its Chief Scientist. At present, the lab is involved primarily in

  • The design of novel algorithms and machine architectures for high-speed molecular dynamics (MD) simulations of proteins and other biological macromolecules
  • The application of such simulations to basic scientific research in structural biology and biochemistry, and to the process of computer-aided drug design

Members of the lab include computational chemists and biologists, computer scientists and applied mathematicians, and computer architects and engineers, all working collaboratively within a tightly coupled interdisciplinary research environment.

Current Projects

  • Initial experimentation with Anton, a specialized supercomputer designed and constructed within our lab that executes MD simulations orders of magnitude faster than was previously possible. A working prototype of the machine recently became operational, and is now undergoing preliminary testing involving the simulation of a number of proteins. We are hopeful that Anton will ultimately allow scientists to observe, among other things, the structural changes that underlie important biological phenomena occurring on time scales far in excess of those that have thus far been computationally accessible.
  • The extension and enhancement of Desmond, a high-performance MD code we designed for use on conventional commodity clusters. Desmond's speed is attributable to novel parallel algorithms and numerical techniques developed within our group. Executable and source code for Desmond is available without cost for non-commercial use at universities and other not-for-profit research institutions. While our lab is not itself engaged in the marketing of software to commercial firms, a license for the commercial use of Desmond is available from Schrödinger, LLC.
    • The development of computational chemistry methods to enable more accurate and effective MD simulations. Our efforts in this area include the creation of improved molecular mechanics force fields, the comparison of simulation results to experimental measurements, and the exploratory development of novel methods for efficiently sampling the conformational space of proteins and other biomolecules.
    • The application of MD simulations to elucidate the functional dynamics of proteins at an atomic level of detail. We are investigating, for example, the mechanisms of several membrane transport proteins, and of certain protein kinases that play a critical role in the development and treatment of cancer. In the course of such research, we have entered into collaborative relationships with several experimental laboratories to help us better understand specific biological systems and to validate predictions that we have made based on our analyses of simulation data.